Given that the genes implicated in AD/FTD were implicated in cholesterol metabolism (APOE, CLU, and ABCA7) and immune response (CR1, CD33, CLU, ABCA7, TREM2, SPPL2A, SCIMP, HLA-DRB1), It is foreseeable that some of the AD variants may be also associated with metabolic/cardiovascular and/or immune-related traits. This evidence concerns the gene SPPL2A and Alzheimer disease.