SPPL2A and Alzheimer disease: Overall, the immune overlap seems to be common to both FTD and AD at the genome level (represented by genome wide significant SNPs used as an instrument variable for AD and other diseases/risk factors except FTD where a p-value threshold of 5 x 10−6 was used because of the smaller GWAS samples size), while there could still be specificity of neuroinflammation for risk variants in CR1, CD33, CLU, ABCA7, TREM2, SORL1, MS4A6A, SPPL2A, SCIMP, PLCG2, ABI3, and HLA-DRB1.