In addition, derangement of electrolyte balances may occur in admitted subjects with MetS, resulting from insulin deficiency, hyperglycemia, dyslipidemia, as a consequence of obesity, as well as administration of drugs such as diuretics, antidiabetic agents or exogenous insulin when compared to their counterparts [3,25,26]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.