The disparity might be due to the majority of participants in this were diabetics in which, patients have insulin resistance with uncontrolled blood sugar were at a greater risk to develop hyponatremia, since the inability of kidney to maintain control of homeostatic mechanisms involving stimulation of thirst, secretion of Antidiuretic Hormone (ADH), and renal handling. The gene discussed is INS; the disease is Hyponatremia.