The expression level of Tie-2 showed a weak, but significant correlation with Ang-2 PP (r = 0.3, p = 0.012) and moderate correlation with Tie-1 IRS and PP (r = 0.5, p <0.001; r = 0.4, p <0.001) in primary cancer of the whole studied population. Here, IARS1 is linked to cancer.