TIE1 and ovarian cancer: In women with primary serous ovarian malignancies, low epithelial expression levels of Tie-1 were significantly associated with a recurrence of ovarian cancer (p = 0.025), with a greater residual tumor size (>1cm) after primary surgery (p = 0.008) and with high grade tumors (p = 0.006) (S3 Table in S1 File).