HBEGF and myeloid sarcoma: This last finding substantially agrees with that of Viehover et al. (2001) showing that NRG levels are markedly reduced in active MS lesions, although previous studies showed that CSF NRG levels are unchanged in MS patients (Pankonin et al. 2009) and that HB-EGF is overexpressed in ASTs in active MS lesions (Schenk et al. 2013).