EGF and multiple sclerosis: Collecting the literature used in this review began at the time of our studies of EGF as a physiological mediator of cobalamin (Cbl) myelinotrophism in human and rat CNS (Scalabrino et al. 1999, 2000), and continued during our studies of CNS EGF levels in multiple sclerosis (MS) (Scalabrino et al. 2010, 2015).