The EGF-related studies dealing with the topic of this section are reported in Table 5C. A schematic diagram depicting: (A) pivotal EGF functions in CNS cell physiology; (B) a key consequence of the EGF lack in MS CNS; and (C) the remyelinating EGF effect in EAE mice and some non-immunological models of rodent CNS demyelination is shown in Fig. 1. This evidence concerns the gene EGF and myeloid sarcoma.