EGF and Peripheral demyelination: There has been a long-running debate about the role of growth factors in EAE models and chemically- or virally-induced CNS demyelination, also because it is emerging from the literature that the expression of some neurotrophic growth factors other than EGF (e.g., IGFs and FGF) is locally up-regulated in rodent CNS with these CNS demyelinating diseases (McMorris and McKinnon 1996; Hinks and Franklin 1999; Franklin and Hinks 1999; Franklin et al 2001; Armstrong 2007; Gudi et al. 2011).