Given that it has been shown that numerous EGFRs are unoccupied and consequently available for EGF ligand in normal CNS (Birecree et al. 1991), it is therefore conceivable that the overwhelming presence of these myelination inhibitors (especially LINGO-1) in MS CNS bind most of the locally available EGFRs, thus preventing the ODC EGFR from binding to the scanty amount of EGF and further reducing new oligodendrogenesis (Aguirre and Gallo 2007). This evidence concerns the gene EGF and myeloid sarcoma.