The possible use of myelinotrophic growth factors (including EGF) to enhance remyelination in MS is supported by papers showing that: (a) several ODC-lineage trophic factors are overexpressed during remyelination after lysolecithin injection in rat CNS (Hinks and Franklin 1999); and (b) a cocktail of many neurotrophic growth factors (other than EGF) promoting the differentiation and proliferation of OPCs and ODCs has been effective in stimulating corpus callosum remyelination in cuprizone-fed mice (Kumar et al. 2007). This evidence concerns the gene EGF and myeloid sarcoma.