STUB1 and Familial prostate cancer: In 20 patients with advanced prostate cancer, we detected a total of 23 pathogenic variants in DNA repair gene variants used for selection of PARPi therapy, from the following source(s): CHIP interference somatic (n = 8, 1 patient had 2), non-CHIP somatic (n = 9), germline (n = 6) (Figure, B).