Using this tool, we firstly observed that in RCC the inhibition of VEGF/R signaling, although affecting tumor growth, rapidly resulted in augmented local tumor invasiveness and increased metastatic dissemination, in accordance with effects reported for other cancer models (Paez‐Ribes et al, 2009; Lu et al, 2012; Sennino et al, 2012). Here, VEGFA is linked to renal cell carcinoma.