Analysis of RNA‐seq data comparing untreated gene expression profiles of pro‐invasive and non‐pro‐invasive tumors suggests that intrinsic features of individual tumors could account for different invasive/metastatic behavior, and pinpoints a KRAS signature as the main difference between them, consistent with findings in other tumor types (Poulin & Haigis, 2017). The gene discussed is KRAS; the disease is neoplasm.