VEGFA and neoplasm: Here, in a “bedside to bench” approximation, we developed a significant collection of Ren‐PDOX models and we found that antiangiogenics could specifically switch on tumor invasiveness and increase systemic dissemination of spontaneously low infiltrative tumors, but in another subset of Ren‐PDOX models, aggressiveness remained unchanged after anti‐VEGF/R therapies.