VEGFA and neoplasm: Specifically in orthotopic patient‐derived model (PDOX), some parallelism exists between clinical results and preclinical observations (Hoffman, 2015), such as in glioblastoma where VEGF‐targeted therapies failed instead inducing vessel cooption and tumor cell spread in patients and PDX models (Lamszus et al, 2005; Norden et al, 2008; Joo et al, 2013).