The IHC analysis of 185 invasive breast cancer lesions done by Karihtala et al. 2007 [129] had the following results: (i) the HA levels in the stroma of all lesions were moderate-to-high and were correlated with sizeable primary tumour size and higher histological grade, with associated high nNOS expression in the cancer cells. Here, NOS1 is linked to neoplasm.