THBS1 and inflammatory bowel disease: Additionally, intussusceptive angiogenesis responsible for the expansion of microvasculature in inflammatory bowel disease was regulated by MT1-MMP and NO, where MT1-MMP cleaved thrombospondin-1 (TSP-1), and the C-terminal fragment of TSP-1 activated eNOS expression and NO production via binding to CD47/αVβ3 integrin [51].