There are increased levels of several inflammatory mediators including interleukin (IL)‐1α, c‐c motif chemokine ligand (CCL) 4, CCL11, CXCL10, CX3CL1, high‐mobility group box 1 (HMGB1), and basic fibroblast growth factor are associated with neuroinflammation in the serum of human patients with epilepsy.8, 9, 10, 11. The gene discussed is HMGB1; the disease is epilepsy.