A total of 25,503 cases of ILD were found in FAERS, of which 161 (0.6%) with CDK4/6 inhibitors, peaking in 2009 (88 cases); a 2-fold increase was noted in the ratio between ILD cases and other events for CDK4/6 inhibitors, as compared to 2018. Here, CDK4 is linked to interstitial lung disease.