CDK4 and interstitial lung disease: Moreover, positive dechallenge supports the reversibility of ILD (reported to occur at therapeutic doses); these clinical elements, together with the observed relatively rapid time to onset (median latency of 63 days for CDK4/6 inhibitors as a class, in line with literature data on anticancer drugs) [27], strengthen the importance of early recognition of signs/symptoms suggestive of ILD (e.g., dyspnea), especially at the beginning of treatment, for appropriate management including drug discontinuation.