DR histological categorization based on the appearance of keloid-like collagen and myxoid stroma, which represent deviant CAF function under the influence of cancer cells, has been shown to be associated with tumor lymphocyte infiltration (12), microvascular density (20), pro-tumor extracellular matrix components (including fibronectin and tenascin-C) (20), mismatch repair status (21), and prognostic outcome in CRC patients (12), (20). The gene discussed is TNC; the disease is colorectal carcinoma.