In addition, CXCL8, CXCL12 and CXCL16 induce angiogenesis in synovial tissue in RA, and CXCL8, CXCL10 and CXCL13 are promising biomarkers of RA disease activity/severity (11), (25). This evidence concerns the gene CXCL8 and rheumatoid arthritis.