Multiple chemokine receptors (CXCR1-6, CCR1, CCR2, CCR5-7, CCR9 and CCR10) and chemokines are all highly expressed in the joints of human RA and in animal models of arthritis (10), (20), (22), (26), (27), (34), (35). Here, CXCR1 is linked to rheumatoid arthritis.