In addition, chemokine receptors control the recruitment of neutrophils (CXCR1 and CXCR2), T helper type 1 (TH1) cell (CXCR3), lymphocyte (CXCR4), B cell (CXCR5), TFH cells (CXCR5), T cell (CXCR6, CCR5 and CCR6), monocyte (CCR1, CCR2, CCR5-7, CCR9 and CCR10) and DCs (CCR9) into the inflamed joints in human RA and in animal models (Figure 1) (10), (17), (18), (19), (20), (22), (23), (26), (35), (36). The gene discussed is CCR2; the disease is rheumatoid arthritis.