It has also been reported that abnormal DNA methylation of different genes such as aldehyde dehydrogenase 1 family member A3 (ALDH1A3), protocadherin 8 (PCDH8), Ras association domain family member 1 (RASSF1), and RUNX family transcription factor 3 (RUNX3) is independently associated with the prognosis of BLCA [7]. The gene discussed is RUNX3; the disease is bladder transitional cell carcinoma.