Although others target genes of TF may also participate in inducing apoptosis via STAT3 and ERK pathways, the present data showed that TF could potentiates chemosensitivity in human NSCLC by suppressing Bcl-2 and Mcl-1 atleast partially, which served a prominent function as an activator in apoptosis by cleavage of PARP and caspases. This evidence concerns the gene BCL2 and non-small cell lung carcinoma.