Although others target genes of TF may also participate in inducing apoptosis via STAT3 and ERK pathways, the present data showed that TF could potentiates chemosensitivity in human NSCLC by suppressing Bcl-2 and Mcl-1 atleast partially, which served a prominent function as an activator in apoptosis by cleavage of PARP and caspases. The gene discussed is STAT3; the disease is non-small cell lung carcinoma.