To date, extensive research has acknowledged numerous DNA-binding TFs that were not only associated with different hallmarks of PAH, but were found to either significantly suppress (PPARG1, MEF2, FOXO1, TP53, KLF4) or aggravate (TWIST1, SLUG, HIF1A, HIF2A, STAT3, HES5, SMAD9, OCT4, KLF5, LEF1, PPARGC1A, CREB1, SRF, NF-KB/ RELA, NFATC2, NFATC3, GATA6, c-JUN, c-FOS, EGR1, CTNNB1, FOXM1) vascular remodeling in vivo125. The gene discussed is TP53; the disease is pulmonary arterial hypertension.