Moreover, high level of miR-139-5p targeting DEmRNAs (CDCA8, KPNA2, PRC1, TOP2A) or risk score generated by 4-DEmRNA signature correlated with advanced clinical characteristics, poor survival and low macrophage infiltration level in HCC, while miR-139-5p showed the contrary result. The gene discussed is TOP2A; the disease is hepatocellular carcinoma.