Furthermore, the massive infiltration of CD68+CD163+ macrophages and total CD68+ macrophages are related to the poor prognosis of HCC patients, while CD68+CD169+ macrophages and CD68+CD38+ macrophages are the opposite (Lam et al., 2019; Li et al., 2017). The gene discussed is SIGLEC1; the disease is hepatocellular carcinoma.