In line with the negative correlation between the expression of hsa-miR-139-5p and targeted DEmRNAs, the expression of cell division cycle associated 8 (CDCA8), karyopherin alpha 2 (KPNA2), polycomb repressive complex 1 (PRC1) or topoisomerase II alpha (TOP2A) was significantly high in advanced pathological grade of HCC in TCGA project (Fig. 5D). This evidence concerns the gene KPNA2 and hepatocellular carcinoma.