SNAP25 and cancer: To our greatest interest, SNAP25 is the most highly interconnected nodes (Fig. 4A), and involves in many cancer-related processes consists of adherens junction, calcium signaling pathway, cytokine receptor interaction, ECM receptor interaction, hedgehog signaling pathway, JAK-STAT signaling pathway, MAPK signaling pathway, TGF beta signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway, and WNT signaling pathway (Fig. 7).