The multivariate Cox regression analysis of TCGA patients with breast cancer showed that IGSF10 was an independent prognostic factor for OS (HR = 1.793, 95% CI [1.141–2.815], P = 0.011) and RFS (HR = 2.298, 95% CI [1.317–4.010], P = 0.003) (Table 2). Here, IGSF10 is linked to breast cancer.