NLRP3 and intracranial hemorrhage: Study has found that NLRP3 inflammasome is involved in aggravating the neuroinflammatory response of SAH and spontaneous intracranial hemorrhage, and its activation is mainly located in microglia (17, 18), while microglia and astrocytes play a key role in the release of pro-inflammatory factors and aggravation of secondary brain injury (19).