The effects of DOX or MLX monotherapy and combination therapy on the levels of TNFα, IL-6, IL-17, IL-10, IL-4, COX-2, BDNF, MMP-3 and TIMP-3 in the brain tissues of the rats with LPS-induced brain inflammation are shown in Figure 1-9, respectively. The gene discussed is BDNF; the disease is brain inflammatory disease.