TGFB1 and fetal growth restriction: Although there are conflicting reports on the involvement of Transforming growth factor-β1 (TGf-β1) a variance of the TGf during placentation, there are however strong indications, implicating TGf-β1 with central roles in cell cycle signaling arrest and apoptosis in normal cellular differentiation in such complications of placenta functions such as preeclampsia and fetal growth restriction (6, 7).