Although there are conflicting reports on the involvement of Transforming growth factor-β1 (TGf-β1) a variance of the TGf during placentation, there are however strong indications, implicating TGf-β1 with central roles in cell cycle signaling arrest and apoptosis in normal cellular differentiation in such complications of placenta functions such as preeclampsia and fetal growth restriction (6, 7). This evidence concerns the gene TGFB1 and preeclampsia.