In addition, WXKL suppressed Ang II-induced elevated expression of CaMKII, CnA, and NFATc4 and prevented Ang II-induced nuclear translocation of NFATc4, suggesting that WXKL attenuated CH by inhibiting the CaMKII and CnA-NFAT signaling pathways. This evidence concerns the gene PPP3CA and cyclic hematopoiesis.