It can also inhibit the Janus kinase 1/signal transducer and activator of transcription 3 (JAK1/STAT3) signaling pathway to reduce the expression of TNF-α, IL-1β, IL-6, MMP-2, MMP-9, iNOS, and COX-2 in RA [94]. Here, MMP2 is linked to rheumatoid arthritis.