There are 32 intersection targets of gout and active compounds of plantain; the key targets are MAPK1, RELA, TNF, NFKBIA, and IFNG and the key pathways include pathways in cancer, HIF-1 signaling pathway, IL-17 signaling pathway, Chagas disease (American trypanosomiasis), and relaxin signaling pathway. This evidence concerns the gene RELA and gout.