It can inhibit the levels of TNF-α, IL-6, IL-1β, IL-17, membrane cation-selective receptor channels (P2X4), nucleotide oligomerization domain-like receptor protein 1 (NLRP1), apoptosis-associated speck-like protein containing CARD (ASC), and caspase-1p10 in RA rats induced by Freund's complete adjuvant and reduce the infiltration of inflammatory cells and synovial hyperplasia [45]. This evidence concerns the gene P2RX4 and rheumatoid arthritis.