The specific mechanism of lncRNA for the regulation of autophagy can be divided into three categories: (1) lncRNA acts as a competitive endogenous RNA-binding miRNA to regulate miRNA expression, thereby affecting the process of autophagy [46]; (2) lncRNA can also affect the expression of ATG genes and (3) lncRNA promotes tumor progression by regulating autophagy-mediated apoptosis through signaling pathways, such as the AKT/mTOR signaling pathway [47]. The gene discussed is AKT1; the disease is neoplasm.