• Enteroviruses activate the inflammasome by acting on NLRP3, caspase-1, ASC, IL-1β and GSDM-D• Ionic imbalances associated with SARS-CoV-2 infections may activate the inflammasome• NLRP3 inflammasome inhibition lowers ALT and AST levels, improving liver fibrosis• Acute pancreatitis activates the NLRP3 inflammasome• The gut-lung axis communicates the lungs with the GI system. The gene discussed is GSDMD; the disease is acute pancreatitis.