There were significant differences in gender distribution, age, height, weight, Hb, TBIL, IBIL, GGT, serum albumin, eGFR, urinary ACR, ABI, omentin-1, OSTA, and BMD at the LS, FN, and TH and corresponding T score, and prevalence of prior fragility fractures, PAD, and DN among the three groups. The gene discussed is ALB; the disease is liver dysplastic nodule.