Although polymorphisms in the TGFBR3 gene, when evaluated individually, have been associated with several clinical manifestations in SCD [14, 20–24, 34, 35], Kim et al. (2010) found that, in asthmatic individuals, these polymorphisms are more informative when evaluated in the context of haplotype, versus on an individual basis [36]. Here, TGFBR3 is linked to Schnyder corneal dystrophy.