Concerning the increase of the LacdiNAc group in aggressive PCa, the β4-N-acetylgalactosaminyltransferase β4GALNT4, which synthetizes the LacdiNAc group on the outer branches of N-glycans has been found upregulated in PCa34,50,56. The gene discussed is B4GALNT4; the disease is posterior cortical atrophy.