PHF6 and precursor B-cell acute lymphoblastic leukemia: Differentiating SK-N-BE (2) cells after PHF6 KO proliferated significantly slower than control cells, while SK-N-BE (2) cells under normal cell culture conditions did not exhibit changes Previous studies showed that stable knockdown of PHF6 in HeLa cells under normal cell culture conditions resulted in decreased cell proliferation starting on day five14, while CRISPR/Cas9 mediated Phf6 KO in B-ALL cells did not show any proliferation changes17, and Phf6 KO in hematopoietic stem cells resulted in better growth77.