CD8A and neoplasm: Because neoantigen presentation and cytolytic T-cell response is governed by MHC class I molecules, which present endogenous antigens on the cell surface of almost all nucleated cells including tumour cells, we hypothesized that the infiltration and distribution of CD8+ T cells might be more directly impacted by the neoantigen presenting capability via the MHC class I molecules to the CD8+ T cells.