Transcriptional analysis revealed that the expression of genes associated with neutrophil recruitment but also activation was increased upon GM-CSF blockade in the blood and lungs from infected mice, suggesting that GM-CSF blockade during M. tuberculosis infection affects not only the recruitment but also the activation status of neutrophils in circulation and at the site of infection, similarly to what was observed during infection of TB-susceptible C3HeB/FeJ mice16. The gene discussed is CSF2; the disease is infection.