However, the observation that lung neutrophil infiltration was found to be reduced in infected Ifnarfl/fl-MRP8-Crepos mice compared to Ifnarfl/fl-MRP8-Creneg mice treated with αGM-CSF mAbs (Fig. 8b), suggests that type I IFN signalling in neutrophils is promoting their recruitment to the site of infection. This evidence concerns the gene S100A8 and infection.