This revealed that, in addition to BRCA1 and BRCA2 (q < 10−5 for both genes, one sided Fisher’s exact test), RAD51C and PALB2 (q < 0.001 and q < 0.05 respectively) were also significantly enriched amongst HRD patients using a q-value threshold of 0.05 (Fig. 3b). Here, PALB2 is linked to hypoparathyroidism-retardation-dysmorphism syndrome.