SLC7A11 and neoplasm: In this context, a recent study showed that the targeted knockout of the substate-specific subunit of system xc−, xCT, in B16F10 melanoma cells almost completely abrogated tumor metastasis and consequently allowed drastically increased survival rates of tumor-bearing mice.5 The findings presented by this and earlier studies thus reinforce the notion that pharmacological targeting of xCT is perhaps one of the most promising strategies to combat disseminating tumor cells.