In vivo VIS832 efficacy was assessed using a murine model xenografted with the dissemination of MM1S-luc cells by i.v. injection into CB-17 SCID mice, which preserve aspects of innate immunity relevant to antibody mechanisms of action29,31,32, including NK cell- and macrophage-mediated cytotoxicity of antibody-targeted CD138-expressing MM cells. Here, SDC1 is linked to Miyoshi myopathy.