In another example, an intergenic C > G mutation 2166 bp from the 3′-UTR of NFE2L2 in a lung cancer case leads to a new junction that pairs with a site embedded in the start of the last exon of NFE2L2 (Fig. 4), potentially disrupting NFE2L2/KEAP1 interaction. This evidence concerns the gene KEAP1 and lung cancer.