In support of the role of APP-DR6 in ALS, we found that DR6 is highly expressed in MNs (Fig. 5a) and that its ablation in these neurons was protective against the toxicity of both mouse mutSOD1 and human sALS astrocytes (Fig. 4), confirming that the identified non-cell autonomous toxic mechanism is not specific to mutSOD1 or mice. The gene discussed is TNFRSF21; the disease is amyotrophic lateral sclerosis.