Although there was no statistical difference in body weight (Figure 8H, P = 0.23) or fasting glucose levels (Figure 8I, P = 0.28), the Ccl2-KO group exhibited higher testis/body weight ratio (P < 0.01, Figure 8J), lower fasting insulin (P < 0.01, Figure 8K), and restored insulin sensitivity (HOMA index, P < 0.01, Figure 8L) as compared with HED-fed WT mice. Here, CCL2 is linked to hypohidrotic ectodermal dysplasia.