CXCR3 and rheumatoid arthritis: Peripheral blood CXCR3+ B cells belonged primarily to the switched memory and DN memory B cell subpopulations, therefore closely resembling the frequency of these cells at the RA synovial tissue (Figure 3, D and F), suggesting that CXCR3 is an important mediator of memory B cell accumulation from the periphery to the site of inflammation in RA.