A negative correlation between the frequency of CXCR3-expressing B cells and disease activity in RA patients, potentially because of increased migration of peripheral blood CXCR3-expressing B cells to the site of inflammation in RA patients with increased disease severity, further reinforces the contribution of CXCR3 in the migration of activated memory B cells and raises the possibility for early therapeutic intervention by inhibiting the CXCR3-mediated synovial migration of memory B cells. This evidence concerns the gene CXCR3 and rheumatoid arthritis.