A study in patients with hepatoma shows PD-1+ B cell IL-10–dependent immune suppression of antitumor T cell responses, while a recent study in thyroid cancer patients highlights high PD-L1 expression and not IL-10 production by tumor PD-1 B cells as being responsible for T cell suppression and cancer survival (19, 30). Here, CD274 is linked to thyroid gland carcinoma.