Importantly, there was a significant inverse correlation (r = –0.6, P = 0.047) between the peripheral blood frequency of CXCR3+ B cells and DAS28-CRP in patients with RA, potentially due to increased migration of CXCR3-expressing B cells to the site of inflammation in patients with higher disease severity, therefore further highlighting the importance of CXCR3 expression for the migration of B cells to the inflamed joint and disease progression (Figure 3G). Here, CRP is linked to rheumatoid arthritis.