Interestingly, our studies found that PAV-206 colocalizes with both of these host enzymes, ABCE1 and DDX6, in the absence of HIV-1 infection (Fig. 10 and 11), suggesting that the compound acts on the host RNA-granule-related RNP complex that is the precursor of assembly intermediates, even in the absence of Gag. The gene discussed is ABCE1; the disease is HIV-1 infection.