NPTX2 and infection: Not surprisingly, several of these genes (e.g., RASD1, NEFM, and NPTX2) have previously been identified as highly upregulated in HSV-1 infection by microarray analysis on total RNA (43, 44), and 10 were significantly upregulated in total RNA at 12 h after WT infection in the Pheasant et al. data (19).