To determine the time window for analysis of the C. elegans ALS-model, we examined the hermaphrodite worms that stably and pan-neuronally express a pathological form of FUS, FUS C-terminal deletion (referred as FUS501 henceforth) (Murakami et al., 2012, 2015) for effects on lifespan and motor function. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.