And in a study by Whitwell et al. employing 18F-AV-1451 to investigate tau deposition in 62 amyloid-positive AD patients with a mix of typical and atypical AD presentations, the authors separated their subjects into three groups (ECLo/CLo, ECLo/CHi, and ECHi/CHi) based on the amount of tau deposition they observed in the entorhinal cortex (EC), as compared to the whole cortex (C) [109]. Here, MAPT is linked to Alzheimer disease.