APOE and Alzheimer disease: Although a more recent study failed to replicate this finding in a set of AD autopsy cases enriched for atypical presentation (in which APOE4 carriers were underrepresented), there did appear to be a trend (p = 0.0992) towards more APOE4 carriers among “limbic predominant” AD cases and fewer APOE4 carriers among “hippocampal-sparing” AD cases [107].