For example, in the previously discussed Lehmann et al. study, where the authors observed regional decreases in Aß deposition in APOE4+ vs. APOE4− AD patients, the authors also reported regional differences in glucose metabolism (as measured by FDG-PET), with APOE4+ AD patients displaying more hypometabolism in bilateral medial temporal and right lateral temporal regions than APOE4− AD patients, while APOE4− AD patients displayed more hypometabolism in other cortical areas, including supplementary motor cortex and superior frontal gyrus [98]. The gene discussed is APOE; the disease is Alzheimer disease.