This suggests that possession of the APOE4 allele may confer increased memory deficits throughout the aging to AD continuum, although it should be noted that APOE4 carriers have also been found to be at an increased risk of developing several non-AD dementias, including vascular dementia (VaD) [68–71], Lewy body dementia (LBD) [72–74], and frontotemporal dementia (FTD) [75, 76], which often do not present with a predominantly amnestic phenotype. The gene discussed is APOE; the disease is Alzheimer disease.