NDUFA11 is a subunit of the membrane bound mitochondrial complex 1 (NADH dehydrogenase) [34] and with the enhancer region hypo-methylated in ME/CFS patients an associated increase in expression may be indicative of a compensatory response to an overall mitochondrial dysfunction, as has been suggested by Missailidis et al. [5]. The gene discussed is NDUFA11; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.