RARA and breast cancer: Starting with hypotheses generated from in silico analysis of NR co-expression and differential co-expression networks, which suggested (1) that MR plays a role in breast cancer biology and (2) that there is potential crosstalk between MR and RAR signalling in the normal breast, which is disrupted in breast cancer, we went on to demonstrate through expression profiling of ligand-treated MR-inducible breast cancer cells that MR and RAR signalling coordinately regulate the expression of a unique set of gene targets that are not significantly changed by either NR alone.