We showed through a combination of in silico and in vitro analyses the convergence of MR and RAR signalling, most likely through RARβ, in normal breast cells to regulate cellular metabolism and general cell maintenance which is disrupted in breast cancer due to the decreased expression of both MR and RARB. Crosstalk in MR and RARβ signalling has not been reported in the breast, although MR and RARβ are members of a group of NR reported to regulate CNS, circadian and basal metabolic response through anatomical profiling of NR expression in the mouse by Bookout et al. [34]. This evidence concerns the gene RARA and breast carcinoma.