To test the functional effect of combined MR-RAR activation on breast cancer growth, we investigated the expression of proliferative genes in ALDO-, RA- and ALDO+RA-treated MR-inducible MCF-7 breast cancer cells, using the known proliferative effect of 17β-estradiol (E2) in MCF-7 cells as reference. This evidence concerns the gene RARA and breast cancer.