Coagulation factor X (FX), a vitamin K-dependent plasma protein, possesses a potent chemotactic ability to recruit macrophages into the tumor tissue via binding to integrin αMβ2 on the macrophage surface and facilitates macrophage differentiation to the M2 subtype by potentiating the phosphorylation and activation of ERK1/2 and AKT [50]. Here, F10 is linked to neoplasm.