TP53 and cancer: Reduction of lncRNA-NEAT1 can curb CD8+ T cell apoptosis and augment its cytolysis activity against cancer by binding to miR-155 targeting Tim-3, a key regulatory factor potentiating CD8+ T cell exhaustion [99]; moreover, through epigenetic suppression of p53/cGAS/STING pathway, NEAT1 directly interacting with DNMT1 to tune CD8+ T cells infiltration and T cell tumor-specific immune response, regulating malignant behavior of cancer cells [98].