A large number of lncRNA expression profiles have changed in mouse and human CD8+ T cells in response to viral infection [167]; of note, the most of lncRNAs expressed in CD8+ T cells harbor signatures of regulated promoters, secondary structures, and evolutionary conservation, indicating many of them are likely to play a part in fate decisions during adaptive immunity of antigen-driven differentiation [168]. The gene discussed is CD8A; the disease is viral infectious disease.