Sandwich ELISA measures of DMR7 provided an EC50 of 0.10 + 0.01 nM for AD-tau, 0.46 + 0.32 nM for AD-P1 PFFs and 12.0 + 7.9 nM for tau monomer, whereas SKT82 EC50 values were 0.17 + 0.03 nM for AD-tau, 2.38 + 1.12 nM for AD-P1 PFFs, and 4.13 + 3.74 nM for tau monomer. The gene discussed is MAPT; the disease is Alzheimer disease.