MAPT and Alzheimer disease: Although we did not detect differences in microglial or astrocytic neuroinflammation in mice treated with SKT82 compared to DMR7 at the end of the study, there may be transient activation of clearance mechanisms induced by SKT82 (IgG2b isotype) at early time points following the initial intracerebral injection of AD-tau or more subtle phenotypic changes to microglia and astrocytes that are not apparent through IHC staining.