Passive immunotherapy studies with the conformation-selective MC1 antibody have demonstrated a reduction in hyperphosphorylated tau pathology but, like most tau mAb efficacy studies, these were evaluated in mouse models with overexpression of mutant human tau [36, 40, 41, 43], whereas DMR7 and SKT82 were evaluated in the context of physiological endogenous mouse tau with AD-tau seeded pathology. Here, ATP7A is linked to Alzheimer disease.