APOE and hyperlipidemia: For example, while impaired binding of APOE2 to LDLR is causally linked to type III hyperlipoproteinemia, characterized by the accumulation of remnants of TG-rich lipoproteins [65, 66, 94, 95], hyperlipidemia is only observed in 5-10% of APOE*ε2/2 homozygotes [94].