In human AD brains, APOE*ε2 carriers and APOE*ε3/3 homozygotes have similar lipidomics profiles, whereas APOE*ε4 carriers have a significant reduction in ten major lipid classes, including phosphatidylethanolamine, phosphatidic acid, and mitochondrial membrane bilayer-forming phospholipids [109]. This evidence concerns the gene APOE and Alzheimer disease.