APOE and Parkinson disease: αSyn pathology in APOE-TR mice induced by adeno-associated viruses (AAV)-mediated overexpression of human wild type αSyn, or in transgenic mice that overexpress the PD-associated mutant, αSyn (A53T), is exacerbated by APOE4, but not by APOE2 or APOE3 [274, 275].