Four genes shown in italic bold on shaded background (TP53, CTNNB1, NF1 and AFF1) are included in Tier 1 of the 576 COSMIC cancer gene census (CGC), while three genes in bold but without italics also on a shaded background (MUC16, MUC4 and PABPC1) are among the 147 CGC Tier 2 genes [COSMIC]. The gene discussed is MUC4; the disease is cancer.