Given that the DLC-1 protein could serve as a degradation target of the CUL4A-DDB1-FBXW5 E3 complex in tumor cells [24], it was of great interest to also determine the involvement of these E3-ligase proteins in regulating DLC-1 protein stability and in the relationship between DLC-1 and Notch1 in hUC-MSCs. This evidence concerns the gene FBXW5 and neoplasm.