It demonstrates for the first time that the DLC-1 tumor suppressor can function as an inhibitor of the immunomodulation of hMSCs, thus further emphasizing the importance of the DLC-1 tumor suppressor in regulating both tumor ‘seed’ and tumor ‘soil’, both of which are critical for tumor development and progression according to the ‘seed-soil’ theory of tumorigenicity [38]. The gene discussed is DLC1; the disease is neoplasm.