Upregulation of ADRP levels [87], PNPLA3/ADI polymorphisms [88], liver lipase (LIPC/HTGL) and lysophospholipase-like protein 1 (LYPLAL1) gene mutations [89,90], and DGAT2 enzymes [91] involved in TG synthesis are also associated with the risk of liver steatosis. Here, LIPC is linked to fatty liver disease.