The aim of this study was to investigate HE4 levels in SARS-Cov-2 patients and the correlation with other inflammatory biomarkers (RCP, IL-6, PSP, PCT, D-Dimer) in order (i) to define which parameters may indicate a greater risk of developing critical forms with less chance of surviving, (ii) to identify the predictive values of these biomarkers for the evolution of the disease and (iii) to evaluate the possible role of HE4 in the defense mechanisms of innate immunity at the level of oral cavity, nasopharynx and respiratory tract. This evidence concerns the gene IL6 and COVID-19.