This is the first study based on clinical evidence and laboratory data that correlated serum levels of He4 in COVID-19 patients with some inflammatory biomarkers (RCP, IL-6, PSP, PCT, D-Dimer) showing the important role of He4 in innate immunity at the level of oral cavity, nasopharynx and respiratory tract and a possible involvement in the onset of smell and/or taste disorders in association with IL-6. This evidence concerns the gene WFDC2 and COVID-19.